1986 :Barry  Bonds, listed at 5-foot-11 and 185 pounds, breaks into the majors as a 21-year-old rookie with the Pittsburgh Pirates. He hits 16 home runs and drives in 48 runs in 113 games.

2000 :
Bond’s personal trainer Greg Anderson introduces Bonds to Victor Conte, a self-taught scientist who boasts he can propel athletes to peak performance through a personalized regimen of nutritional supplements.

2001 Bonds, now listed at 6-foot-2 and 228 pounds, hits a season-record 73 home runs and wins his fourth National League MVP award, also a record. Bonds also amasses season records for total walks (177) and slugging percentage (.863).
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in April 2002,  Bonds was interviewed by Bob Costas:

Costas: "For the record, have you ever used steroids?"
Bonds: "No."
Costas: "Would you ever consider using them under any circumstances?"
Bonds: "No. I don't have to. I mean, I'm a good enough ballplayer as it is. I don't need to be any better. I can't get any better at this age."
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I drew this picture of Barry Bonds just before going to Game 4 of the 2002 world series, in which the Giants came within one game of winning it all. It was a great day. It seems a little less great now.